How is a complete response defined in RECIST 1.1?

How is a complete response defined in RECIST 1.1?

• A. Disappearance of all target lesions.
• B. At least 30% decrease in lesion size.
• C. Progression by 20% or more.
• D. No change in lesions.

Answer: (A)

RECIST 1.1 defines a complete response as the disappearance of all target lesions, with no new lesions appearing. This is the strict criterion for CR, meaning there is no radiographic evidence of disease in the tracked target sites. The other scenarios describe different response categories: a substantial shrinkage qualifies as partial response, a new lesion or a significant increase in lesion size qualifies as progression, and no meaningful change qualifies as stable disease.

RECIST 1.1 defines a complete response as the disappearance of all target lesions, with no new lesions appearing. This is the strict criterion for CR, meaning there is no radiographic evidence of disease in the tracked target sites. The other scenarios describe different response categories: a substantial shrinkage qualifies as partial response, a new lesion or a significant increase in lesion size qualifies as progression, and no meaningful change qualifies as stable disease.