Mitotic inhibitors disrupt which cellular process?

Mitotic inhibitors disrupt which cellular process?

• A. DNA replication
• B. Mitosis
• C. Transcription
• D. Protein synthesis

Answer: (B)

Mitotic inhibitors disrupt the process of cell division during mitosis. They interfere with microtubule dynamics and the spindle apparatus, which are essential for chromosomes to align on the metaphase plate and then separate during anaphase. By blocking these steps, cells cannot complete mitosis, leading to cell cycle arrest and death in rapidly dividing cancer cells. This is different from DNA replication, which occurs earlier in the cell cycle (S phase), and from transcription or protein synthesis, which occur outside of mitosis. So the cellular process most affected is mitosis.

Mitotic inhibitors disrupt the process of cell division during mitosis. They interfere with microtubule dynamics and the spindle apparatus, which are essential for chromosomes to align on the metaphase plate and then separate during anaphase. By blocking these steps, cells cannot complete mitosis, leading to cell cycle arrest and death in rapidly dividing cancer cells. This is different from DNA replication, which occurs earlier in the cell cycle (S phase), and from transcription or protein synthesis, which occur outside of mitosis. So the cellular process most affected is mitosis.