Which regional route delivers chemotherapy into the cerebrospinal fluid?

Which regional route delivers chemotherapy into the cerebrospinal fluid?

• A. Intraarterial
• B. Intraperitoneal
• C. Intrathecal
• D. Intravesical

Answer: (C)

Delivering chemotherapy into the cerebrospinal fluid is done intrathecally. This approach places the drug directly into the CSF through a lumbar puncture or an implanted reservoir, allowing distribution throughout the CNS and bypassing the blood–brain barrier that often limits systemic chemotherapy. It’s particularly used for CNS or leptomeningeal involvement, where achieving therapeutic CSF concentrations is crucial. The other routes target different spaces: intraarterial delivers through arteries to concentrate in brain tissue, intraperitoneal puts drug into the peritoneal cavity, and intravesical instills it into the bladder.

Delivering chemotherapy into the cerebrospinal fluid is done intrathecally. This approach places the drug directly into the CSF through a lumbar puncture or an implanted reservoir, allowing distribution throughout the CNS and bypassing the blood–brain barrier that often limits systemic chemotherapy. It’s particularly used for CNS or leptomeningeal involvement, where achieving therapeutic CSF concentrations is crucial. The other routes target different spaces: intraarterial delivers through arteries to concentrate in brain tissue, intraperitoneal puts drug into the peritoneal cavity, and intravesical instills it into the bladder.